Seroatlas · Human Serome Atlas

PROCA1

Protein PROCA1

Also known as: MGC39650, PRCA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCQ7
Gene: PROCA1
Ensembl: ENSG00000167525
Chromosome: 17
Canonical length: 364 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Golgi apparatus

OverviewNCBI Gene

Enables cyclin binding activity. Predicted to be involved in arachidonate secretion and phospholipid metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

364 residues, UniProt reviewed canonical sequence.

>Q8NCQ7|PROCA1
     1  MWVRTTLTIE RWTKEKTEPK ARSWDEALSD VNRLPSWERG HLLAGVASST DVSTFSEGGD
    61  CKEPDKCCWR HKQCTGHIIY PFASDCVRHS LHLHSVNHCN CNSRLKDSSE DSSSSRGAGP
   121  TCSHVIESPC FELTPEEEHV ERFRYGWCKS YRPVSVAVIH HPLYHECGAD DLNEEEEEEE
   181  EESKPPIPTQ VGPATASPDL GTSMATGTPD STAPITIWRS ESPTGKGQGS KVIKKVKKKK
   241  EKEKDKEEMD EKAKLKKKAK KGQLTKKKSP VKLEPSPPDV SRSLSARQLA RMSESSPESR
   301  EELESEDSYN GRGQGELSSE DIVESSSPRK RENTVQAKKT GAKPSQARKV NKRKSPPGSN
   361  PNLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROCA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

testis: 122 nTPM
spleen: 5.8 nTPM
choroid plexus: 4.6 nTPM
cerebellum: 4.5 nTPM
kidney: 3.7 nTPM
basal ganglia: 3.5 nTPM

Single-cell type

late spermatids: 12,076 nCPM
early spermatids: 1,860 nCPM
late primary spermatocytes: 664 nCPM
tuft cells: 58 nCPM
early primary spermatocytes: 26 nCPM
sertoli cells: 17 nCPM

Immune cell

basophil: 5 nTPM
eosinophil: 3.6 nTPM
plasmacytoid DC: 2.5 nTPM
memory B-cell: 2 nTPM
intermediate monocyte: 1.7 nTPM
non-classical monocyte: 1.3 nTPM

Brain region

medulla oblongata: 3.4 nTPM
cerebellum: 3.2 nTPM
cerebral cortex: 3.1 nTPM
midbrain: 2.6 nTPM
pons: 2.4 nTPM
white matter: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PROCA1 as an antibody target. Whether an autoantibody or antibody against PROCA1 could matter depends on whether native PROCA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PROCA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PROCA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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