Seroatlas · Human Serome Atlas

PRO2289

Putative uncharacterized protein PRO2289

Also known as: YP008_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1D8
Gene: PRO2289
Canonical length: 64 aa

OverviewNCBI Gene

No narrative summary is available for PRO2289 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

64 residues, UniProt reviewed canonical sequence.

>Q9P1D8|PRO2289
     1  MMITRGWEGW GRRGARGAGT GTGLGGPGTP ESSVTPPEFP LPPATRITPN FPNTLDPAIS
    61  RSSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRO2289 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.76

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRO2289 as an antibody target. Whether an autoantibody or antibody against PRO2289 could matter depends on whether native PRO2289 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRO2289 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRO2289 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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