Seroatlas · Human Serome Atlas

PRO0461

Putative uncharacterized protein PRO0461

Also known as: YP002_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UI25
Gene: PRO0461
Canonical length: 63 aa

OverviewNCBI Gene

No narrative summary is available for PRO0461 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

63 residues, UniProt reviewed canonical sequence.

>Q9UI25|PRO0461
     1  MEEMSYGENS GTHVGSFSCS PQPSQQMKVL FVGNSFLLTP VLHRQPHLQP CNFGPEVVAP
    61  QRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRO0461 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRO0461 as an antibody target. Whether an autoantibody or antibody against PRO0461 could matter depends on whether native PRO0461 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRO0461 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRO0461 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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