Seroatlas · Human Serome Atlas

PRNT

Putative testis-specific prion protein

Also known as: PRNT_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86SH4
Gene: PRNT
Canonical length: 94 aa

OverviewNCBI Gene

No narrative summary is available for PRNT in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>Q86SH4|PRNT
     1  MQHSLVFFFA VILHLSHLLH LDASIHPFRL PFSSKPFLLI PMSNTTLPHT AWPLSFLHQT
    61  VSTLKAVAVT HSLWHLQIPV DCQACNRKSK KIYC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRNT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.33

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Putative testis-specific prion protein
Prion-related protein testis-specific

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRNT as an antibody target. Whether an autoantibody or antibody against PRNT could matter depends on whether native PRNT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRNT is annotated as secreted, so native PRNT circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRNT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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