PRND
Prion-like protein doppel
Also known as: dJ1068H6.4, DOPPEL, DPL, PRND_HUMAN, PrPLP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UKY0
- Gene
- PRND
- Ensembl
- ENSG00000171864
- Chromosome
- 20
- Canonical length
- 176 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
176 residues, UniProt reviewed canonical sequence.
>Q9UKY0|PRND
1 MRKHLSWWWL ATVCMLLFSH LSAVQTRGIK HRIKWNRKAL PSTAQITEAQ VAENRPGAFI
61 KQGRKLDIDF GAEGNRYYEA NYWQFPDGIH YNGCSEANVT KEAFVTGCIN ATQAANQGEF
121 QKPDNKLHQQ VLWRLVQELC SLKHCEFWLE RGAGLRVTMH QPVLLCLLAL IWLTVKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRND can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 66 nTPM
Expression across tissuesHPA
Tissue
- testis: 66 nTPM
- choroid plexus: 38 nTPM
- endometrium: 3.2 nTPM
- colon: 1.8 nTPM
- smooth muscle: 1.2 nTPM
- gallbladder: 1.1 nTPM
Single-cell type
- sertoli cells: 100 nCPM
- epididymal efferent duct absorptive cells: 6.3 nCPM
- late spermatids: 6.2 nCPM
- choroid plexus epithelial cells: 4.8 nCPM
- retinal pigment epithelial cells: 4.3 nCPM
- epicardial cells: 2.3 nCPM
Immune cell
- basophil: 0.3 nTPM
- neutrophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- choroid plexus: 68 nTPM
- hippocampal formation: 2.7 nTPM
- cerebellum: 2.1 nTPM
- thalamus: 2 nTPM
- hypothalamus: 1.4 nTPM
- medulla oblongata: 1.3 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about PRND.
Disease | ImmuneIEDB
Conditions an epitope on PRND was assayed in.
- hepatocellular carcinoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.68
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.11
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Prion/Doppel protein, beta-ribbon domain
- Prion/Doppel beta-ribbon domain superfamily
- Prion/Doppel alpha-helical domain
- Prion-like protein Doppel
- Prion-like protein Doppel
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRND as an antibody target. Whether an autoantibody or antibody against PRND could matter depends on whether native PRND is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRND is annotated at the cell surface, where native PRND is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label PRND as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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