Seroatlas · Human Serome Atlas

PRM3

Protamine-3

Also known as: PRM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NNZ6
Gene
PRM3
Ensembl
ENSG00000178257
Chromosome
16
Canonical length
103 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable DNA binding activity. Predicted to be involved in flagellated sperm motility. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

103 residues, UniProt reviewed canonical sequence.

>Q9NNZ6|PRM3
     1  MGSRCAKLNT GQSPGHSPGH STGHGRGHES SMKKLMACVS QDNFSLSSAG EEEEEEEEEG
    61  EEEEKEELPV QGKLLLLEPE RQEEGHKDNA EAQQSPEPKR TPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • testis: 81 nTPM
  • bone marrow: 2.5 nTPM
  • retina: 1.2 nTPM
  • skin: 0.6 nTPM
  • duodenum: 0.2 nTPM
  • lymph node: 0.2 nTPM

Single-cell type

  • late spermatids: 5,420 nCPM
  • early spermatids: 1,035 nCPM
  • late primary spermatocytes: 178 nCPM
  • sertoli cells: 11 nCPM
  • leydig cells: 6.3 nCPM
  • peritubular myoid cells: 4.1 nCPM

Immune cell

  • naive CD8 T-cell: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 7.5 nTPM
  • cerebral cortex: 4.7 nTPM
  • basal ganglia: 3.5 nTPM
  • amygdala: 2.8 nTPM
  • hippocampal formation: 2.1 nTPM
  • white matter: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.79
gnomAD pLI
0.36
gnomAD missense Z
0.04

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Protamine-P3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRM3 as an antibody target. Whether an autoantibody or antibody against PRM3 could matter depends on whether native PRM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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