PRM1
Sperm protamine P1
Also known as: CT94.1, HSP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P04553
- Gene
- PRM1
- Ensembl
- ENSG00000175646
- Chromosome
- 16
- Canonical length
- 51 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Predicted to enable DNA binding activity. Predicted to be involved in chromosome organization and spermatogenesis. Predicted to act upstream of or within nucleus organization and spermatid development. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
51 residues, UniProt reviewed canonical sequence.
>P04553|PRM1
1 MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR HLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PRM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 15,140 nTPM
Expression across tissuesHPA
Tissue
- testis: 15,140 nTPM
- prostate: 12 nTPM
- breast: 9.7 nTPM
- colon: 5.9 nTPM
- skeletal muscle: 5.9 nTPM
- liver: 5.2 nTPM
Single-cell type
- late spermatids: 1,088,816 nCPM
- early spermatids: 140,472 nCPM
- late primary spermatocytes: 6,593 nCPM
- leydig cells: 831 nCPM
- sertoli cells: 779 nCPM
- peritubular myoid cells: 583 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 0.4 nTPM
- pons: 0.3 nTPM
- medulla oblongata: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- cerebellum: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.87
- gnomAD pLI
- 0.03
- gnomAD missense Z
- -0.54
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Protamine P1
- Protamine P1
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PRM1 as an antibody target. Whether an autoantibody or antibody against PRM1 could matter depends on whether native PRM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PRM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PRM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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