Seroatlas · Human Serome Atlas

PRLH

Prolactin-releasing peptide

Also known as: PRH, PRRP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P81277
Gene: PRLH
Ensembl: ENSG00000071677
Chromosome: 2
Canonical length: 87 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in brain

OverviewNCBI Gene

Predicted to enable neuropeptide hormone activity and prolactin-releasing peptide receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; feeding behavior; and response to peptide hormone. Predicted to act upstream of or within several processes, including fat cell differentiation; reduction of food intake in response to dietary excess; and response to insulin. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

87 residues, UniProt reviewed canonical sequence.

>P81277|PRLH
     1  MKVLRAWLLC LLMLGLALRG AASRTHRHSM EIRTPDINPA WYASRGIRPV GRFGRRRATL
    61  GDVPKPGLRP RLTCFPLEGG AMSSQDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRLH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 1.7 nTPM
heart muscle: 1 nTPM
fallopian tube: 0.4 nTPM
thymus: 0.3 nTPM
hypothalamus: 0.2 nTPM
pituitary gland: 0.2 nTPM

Single-cell type

breast hormone-responsive cells: 1 nCPM
alveolar cells type 2: 0.7 nCPM
gonadotrophs: 0.7 nCPM
undifferentiated spermatogonia: 0.7 nCPM
endometrial ciliated cells: 0.5 nCPM
other brain neurons: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 48 nTPM
white matter: 17 nTPM
spinal cord: 11 nTPM
hypothalamus: 2.6 nTPM
pons: 1.2 nTPM
cerebral cortex: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.11
gnomAD missense Z: -0.64
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hormone activity
neuropeptide hormone activity
prolactin-releasing peptide receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prolactin-releasing peptide
Prolactin-releasing peptide

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRLH as an antibody target. Whether an autoantibody or antibody against PRLH could matter depends on whether native PRLH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRLH is annotated as secreted, so native PRLH circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRLH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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