Seroatlas · Human Serome Atlas

PRKY

Putative serine/threonine-protein kinase PRKY

Also known as: PRKY_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43930
Gene: PRKY
Canonical length: 277 aa

OverviewNCBI Gene

No narrative summary is available for PRKY in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>O43930|PRKY
     1  MEAPGPAQAA AAESNSREVT EDAADWAPAL CPSPEARSPE APAYRLQDCD ALVTMGTGTF
    61  GRVHLVKEKT AKHFFALKVM SIPDVIRRKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHEER
   121  FLYMLMEYVP GGELFSYLRN RGHFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL
   181  DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG
   241  FPPFFDDNPF GIYQKILAGK LYFPRHLDFH VKTGRMM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRKY as an antibody target. Whether an autoantibody or antibody against PRKY could matter depends on whether native PRKY is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRKY is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRKY as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...