PRKG2

Protein identityUniProt · HPA

UniProt accession

Q13237

Gene

PRKG2

Ensembl

ENSG00000138669

Chromosome

4

Canonical length

762 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]

Canonical amino-acid sequenceUniProt

762 residues, UniProt reviewed canonical sequence.

>Q13237|PRKG2
     1  MGNGSVKPKH SKHPDGHSGN LTTDALRNKV TELERELRRK DAEIQEREYH LKELREQLSK
    61  QTVAIAELTE ELQNKCIQLN KLQDVVHMQG GSPLQASPDK VPLEVHRKTS GLVSLHSRRG
   121  AKAGVSAEPT TRTYDLNKPP EFSFEKARVR KDSSEKKLIT DALNKNQFLK RLDPQQIKDM
   181  VECMYGRNYQ QGSYIIKQGE PGNHIFVLAE GRLEVFQGEK LLSSIPMWTT FGELAILYNC
   241  TRTASVKAIT NVKTWALDRE VFQNIMRRTA QARDEQYRNF LRSVSLLKNL PEDKLTKIID
   301  CLEVEYYDKG DYIIREGEEG STFFILAKGK VKVTQSTEGH DQPQLIKTLQ KGEYFGEKAL
   361  ISDDVRSANI IAEENDVACL VIDRETFNQT VGTFEELQKY LEGYVANLNR DDEKRHAKRS
   421  MSNWKLSKAL SLEMIQLKEK VARFSSSSPF QNLEIIATLG VGGFGRVELV KVKNENVAFA
   481  MKCIRKKHIV DTKQQEHVYS EKRILEELCS PFIVKLYRTF KDNKYVYMLL EACLGGELWS
   541  ILRDRGSFDE PTSKFCVACV TEAFDYLHRL GIIYRDLKPE NLILDAEGYL KLVDFGFAKK
   601  IGSGQKTWTF CGTPEYVAPE VILNKGHDFS VDFWSLGILV YELLTGNPPF SGVDQMMTYN
   661  LILKGIEKMD FPRKITRRPE DLIRRLCRQN PTERLGNLKN GINDIKKHRW LNGFNWEGLK
   721  ARSLPSPLQR ELKGPIDHSY FDKYPPEKGM PPDELSGWDK DF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKG2.

Disease | AllUniProt

Conditions PRKG2 is implicated in, by any mechanism.

• Spondylometaphyseal dysplasia, Pagnamenta type (SMDP) MIM:619638
• Acromesomelic dysplasia 4 (AMD4) MIM:619636

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Acromesomelic dysplasia 4
• Spondylometaphyseal dysplasia, pagnamenta type

Disease | ImmuneIEDB

Conditions an epitope on PRKG2 was assayed in.

• narcolepsy B cell
• multiple sclerosis B cell
• peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.37

gnomAD pLI

0.65

gnomAD missense Z

2.99

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular signal transduction
• negative regulation of chloride transport
• positive regulation of chondrocyte differentiation
• positive regulation of protein localization
• protein localization to plasma membrane
• signal transduction
• tetrahydrobiopterin metabolic process

Molecular functions

• ATP binding
• cGMP binding
• cGMP-dependent protein kinase activity
• identical protein binding
• mitogen-activated protein kinase binding
• protein serine kinase activity

Cellular components

• apical plasma membrane
• cytosol
• nuclear membrane

Protein domainsUniProt · Pfam · InterPro

• Cyclic nucleotide-binding domain
• Protein kinase domain
• AGC-kinase, C-terminal
• cGMP-dependent kinase
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• RmlC-like jelly roll fold
• Protein kinase, ATP binding site
• Cyclic nucleotide-binding, conserved site
• Cyclic nucleotide-binding domain superfamily
• cGMP-dependent protein kinase, catalytic domain
• Cyclic nucleotide-binding domain
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Cell membrane
• cGMP
• cGMP-binding
• Coiled coil
• Dwarfism
• Kinase
• Lipoprotein
• Membrane
• Myristate
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PRKG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GRIA1