PRKACG

Protein identityUniProt · HPA

UniProt accession

P22612

Gene

PRKACG

Ensembl

ENSG00000165059

Chromosome

9

Canonical length

351 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Microtubules,Cytokinetic bridge,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

351 residues, UniProt reviewed canonical sequence.

>P22612|PRKACG
     1  MGNAPAKKDT EQEESVNEFL AKARGDFLYR WGNPAQNTAS SDQFERLRTL GMGSFGRVML
    61  VRHQETGGHY AMKILNKQKV VKMKQVEHIL NEKRILQAID FPFLVKLQFS FKDNSYLYLV
   121  MEYVPGGEMF SRLQRVGRFS EPHACFYAAQ VVLAVQYLHS LDLIHRDLKP ENLLIDQQGY
   181  LQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAVGFPPFY
   241  ADQPIQIYEK IVSGRVRFPS KLSSDLKHLL RSLLQVDLTK RFGNLRNGVG DIKNHKWFAT
   301  TSWIAIYEKK VEAPFIPKYT GPGDASNFDD YEEEELRISI NEKCAKEFSE F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRKACG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

23 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRKACG.

Disease | AllUniProt

Conditions PRKACG is implicated in, by any mechanism.

• Bleeding disorder, platelet-type, 19 (BDPLT19) MIM:616176

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z

-0.18

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-activating G protein-coupled receptor signaling pathway
• high-density lipoprotein particle assembly
• male gonad development
• positive regulation of insulin secretion
• renal water homeostasis
• spermatogenesis
• vascular endothelial cell response to laminar fluid shear stress

Molecular functions

• ATP binding
• cAMP-dependent protein kinase activity
• potassium channel inhibitor activity
• protein kinase A regulatory subunit binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cAMP-dependent protein kinase complex
• ciliary base
• cytosol
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• AGC-kinase, C-terminal
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• cAMP-dependent protein kinase catalytic subunit
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• cAMP
• Kinase
• Lipoprotein
• Myristate
• Nucleotide-binding
• Phosphoprotein
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PRKACG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRKAR2A
• PRKAR2B