Seroatlas · Human Serome Atlas

PRIMA1

Proline-rich membrane anchor 1

Also known as: PRIMA, PRIMA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XR5
Gene: PRIMA1
Ensembl: ENSG00000175785
Chromosome: 14
Canonical length: 153 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoli,Plasma membrane,Cytosol

OverviewNCBI Gene

The product of this gene functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>Q86XR5|PRIMA1
     1  MLLRDLVLRR GCCWSSLLLH CALHPLWGFV QVTHGEPQKS CSKVTDSCRH VCQCRPPPPL
    61  PPPPPPPPPP RLLSAPAPNS TSCPTEESWW SGLVIIIAVC CASLVFLTVL VIICYKAIKR
   121  KPLRKDENGT SVAEYPMSAS QSNKGVDVNN AVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRIMA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

colon: 53 nTPM
spinal cord: 45 nTPM
fallopian tube: 21 nTPM
small intestine: 20 nTPM
stomach: 19 nTPM
endometrium: 17 nTPM

Single-cell type

oligodendrocytes: 87 nCPM
other brain neurons: 30 nCPM
ependymal cells: 22 nCPM
bergmann glia: 18 nCPM
schwann cells: 11 nCPM
loop of henle epithelial cells: 5.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 33 nTPM
medulla oblongata: 33 nTPM
pons: 27 nTPM
cerebral cortex: 25 nTPM
spinal cord: 22 nTPM
midbrain: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRIMA1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 167 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Familial sleep-related hypermotor epilepsy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.63
gnomAD missense Z: 0.98
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proline-rich membrane anchor 1
Proline-rich membrane anchor 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRIMA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACHE

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRIMA1 as an antibody target. Whether an autoantibody or antibody against PRIMA1 could matter depends on whether native PRIMA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRIMA1 is annotated at the cell surface, where native PRIMA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRIMA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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