PRH1

Protein identityUniProt · HPA

UniProt accession

P02810

Gene

PRH1

Ensembl

ENSG00000134551

Chromosome

12

Canonical length

166 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>P02810|PRH1
     1  MLLILLSVAL LAFSSAQDLD EDVSQEDVPL VISDGGDSEQ FIDEERQGPP LGGQQSQPSA
    61  GDGNQNDGPQ QGPPQQGGQQ QQGPPPPQGK PQGPPQQGGH PPPPQGRPQG PPQQGGHPRP
   121  PRGRPQGPPQ QGGHQQGPPP PPPGKPQGPP PQGGRPQGPP QGQSPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.72

Highest tissue expression

21,602 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRH1.

Disease | AutoantibodyPubMed

Conditions in which antibodies against PRH1 are reported. Each links to that disease's full target list.

• Antiphospholipid Syndrome 7
• Thrombosis 6
• Lupus Erythematosus, Systemic 4

Showing 3 of 5 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PRH1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0.01

gnomAD missense Z

0.69

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Proline-rich protein
• Proline-rich protein

KeywordsUniProt

• Cleavage on pair of basic residues
• Glycoprotein
• Phosphoprotein
• Pyrrolidone carboxylic acid
• Repeat
• Secreted
• Signal