Seroatlas · Human Serome Atlas

PRELID2

PRELI domain-containing protein 2

Also known as: FLJ38376, MGC21644, PRLD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N945
Gene: PRELID2
Ensembl: ENSG00000186314
Chromosome: 5
Canonical length: 189 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q8N945|PRELID2
     1  MGVSVDVHQV YKYPFEQVVA SFLRKYPNPM DKNVISVKIM EEKRDESTGV IYRKRIAICQ
    61  NVVPEILRKS LSTLVILCWK KVSILKVPNI QLEEESWLNP RERNMAIRSH CLTWTQYASM
   121  KEESVFRESM ENPNWTEFIQ RGRISITGVG FLNCVLETFA STFLRQGAQK GIRIMEMLLK
   181  EQCGAPLAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRELID2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

small intestine: 21 nTPM
colon: 15 nTPM
rectum: 15 nTPM
retina: 15 nTPM
duodenum: 9.3 nTPM
stomach: 6.9 nTPM

Single-cell type

cone photoreceptor cells: 2,118 nCPM
retinal bipolar cells: 483 nCPM
enterocytes: 391 nCPM
cardiomyocytes: 378 nCPM
rod photoreceptor cells: 322 nCPM
colonocytes: 309 nCPM

Immune cell

basophil: 24 nTPM
myeloid DC: 5.5 nTPM
T-reg: 2.3 nTPM
intermediate monocyte: 2.2 nTPM
NK-cell: 2.1 nTPM
memory B-cell: 1.7 nTPM

Brain region

white matter: 16 nTPM
cerebral cortex: 16 nTPM
thalamus: 13 nTPM
medulla oblongata: 13 nTPM
spinal cord: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRELID2 as an antibody target. Whether an autoantibody or antibody against PRELID2 could matter depends on whether native PRELID2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRELID2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRELID2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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