Seroatlas · Human Serome Atlas

PRCD

Photoreceptor disk component PRCD

Also known as: PRCD_HUMAN, RP36

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q00LT1
Gene
PRCD
Ensembl
ENSG00000214140
Chromosome
17
Canonical length
54 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

54 residues, UniProt reviewed canonical sequence.

>Q00LT1|PRCD
     1  MCTTLFLLST LAMLWRRRFA NRVQPEPSDV DGAARGSSLD ADPQSSGREK EPLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • retina: 45 nTPM
  • cerebellum: 4.6 nTPM
  • heart muscle: 1.2 nTPM
  • spleen: 1 nTPM
  • adipose tissue: 0.9 nTPM
  • breast: 0.9 nTPM

Single-cell type

  • rod photoreceptor cells: 331 nCPM
  • cone photoreceptor cells: 95 nCPM
  • retinal bipolar cells: 60 nCPM
  • retinal pigment epithelial cells: 43 nCPM
  • pericytes: 32 nCPM
  • b-cells: 27 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 7.7 nTPM
  • choroid plexus: 5.2 nTPM
  • pons: 5 nTPM
  • medulla oblongata: 3.4 nTPM
  • cerebral cortex: 3.3 nTPM
  • midbrain: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRCD.

Disease | AllUniProt

Conditions PRCD is implicated in, by any mechanism.

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 149 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0.02
gnomAD missense Z
0.3
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Photoreceptor disk component PRCD
  • Progressive rod-cone degeneration

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRCD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRCD as an antibody target. Whether an autoantibody or antibody against PRCD could matter depends on whether native PRCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRCD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRCD. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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