Seroatlas · Human Serome Atlas

PRCC

Proline-rich protein PRCC

Also known as: PRCC_HUMAN, RCCP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92733
Gene
PRCC
Ensembl
ENSG00000143294
Chromosome
1
Canonical length
491 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nuclear speckles

OverviewNCBI Gene

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q92733|PRCC
     1  MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL LPPPPQMLAP
    61  AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE AAGVGEGLGL GLPSPRGPGL
   121  NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL
   181  SALLPQPKNL TVKETNRLLL PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP
   241  SPSAIKAAAK SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE
   301  ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY GDANAAGAYY
   361  QDYYSGGYYP AQDPALVPPQ EIAPDASFID DEAFKRLQGK RNRGREEINF VEIKGDDQLS
   421  GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ QRRKHQITYL IHQAKERELE LKNTWSENKL
   481  SRRQTQAKYG F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 62 nTPM
  • skin: 42 nTPM
  • cerebellum: 40 nTPM
  • bone marrow: 40 nTPM
  • choroid plexus: 39 nTPM
  • esophagus: 39 nTPM

Single-cell type

  • syncytiotrophoblasts: 136 nCPM
  • migrating cytotrophoblasts: 87 nCPM
  • extravillous trophoblasts: 82 nCPM
  • cytotrophoblasts: 80 nCPM
  • esophageal apical cells: 66 nCPM
  • plasma cells: 63 nCPM

Immune cell

  • eosinophil: 58 nTPM
  • basophil: 47 nTPM
  • plasmacytoid DC: 39 nTPM
  • non-classical monocyte: 37 nTPM
  • myeloid DC: 33 nTPM
  • NK-cell: 30 nTPM

Brain region

  • white matter: 49 nTPM
  • cerebral cortex: 47 nTPM
  • cerebellum: 45 nTPM
  • basal ganglia: 45 nTPM
  • hippocampal formation: 44 nTPM
  • pons: 44 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
1.09
DepMap mean gene effect
-0.41
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Proline-rich protein PRCC
  • Mitotic checkpoint regulator, MAD2B-interacting

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRCC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRCC as an antibody target. Whether an autoantibody or antibody against PRCC could matter depends on whether native PRCC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRCC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRCC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRCC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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