Seroatlas · Human Serome Atlas

PRB4

Basic salivary proline-rich protein 4

Also known as: PRB4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P10163
Gene: PRB4
Canonical length: 310 aa
Protein class: Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for PRB4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>P10163|PRB4
     1  MLLILLSVAL LALSSAESSS EDVSQEESLF LISGKPEGRR PQGGNQPQRP PPPPGKPQGP
    61  PPQGGNQSQG PPPPPGKPEG RPPQGGNQSQ GPPPHPGKPE RPPPQGGNQS QGPPPHPGKP
   121  ESRPPQGGHQ SQGPPPTPGK PEGPPPQGGN QSQGTPPPPG KPEGRPPQGG NQSQGPPPHP
   181  GKPERPPPQG GNQSHRPPPP PGKPERPPPQ GGNQSQGPPP HPGKPEGPPP QEGNKSRSAR
   241  SPPGKPQGPP QQEGNKPQGP PPPGKPQGPP PAGGNPQQPQ APPAGKPQGP PPPPQGGRPP
   301  RPAQGQQPPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 3,431 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 3,431 nTPM
lung: 16 nTPM
testis: 0.3 nTPM
skin: 0.2 nTPM
pituitary gland: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

salivary acinar cells: 4,714 nCPM
salivary myoepithelial cells: 2,482 nCPM
neutrophils: 312 nCPM
submucosal glandular cells: 116 nCPM
t-cells: 75 nCPM
monocytes: 51 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1.1 nTPM
cerebral cortex: 0.8 nTPM
hypothalamus: 0.7 nTPM
thalamus: 0.7 nTPM
medulla oblongata: 0.6 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.98
gnomAD pLI: 0
gnomAD missense Z: -3.21
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRB4 as an antibody target. Whether an autoantibody or antibody against PRB4 could matter depends on whether native PRB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRB4 is annotated as secreted, so native PRB4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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