Seroatlas · Human Serome Atlas

PRB2

Basic salivary proline-rich protein 2

Also known as: cP7, PRB2_HUMAN, PRPPRB1, Ps

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P02812
Gene
PRB2
Ensembl
ENSG00000121335
Chromosome
12
Canonical length
416 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats, polymorphic cleavage sites and polymorphic stop codons have been identified. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. [provided by RefSeq, May 2023]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>P02812|PRB2
     1  MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGAP PQGGNKPQGP PSPPGKPQGP
    61  PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSRS PRSPPGKPQG
   121  PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ GPPPQGDNKS RSSRSPPGKP
   181  QGPPPQGGNQ PQGPPPPPGK PQGPPPQGGN KPQGPPPPGK PQGPPPQGDN KSQSARSPPG
   241  KPQGPPPQGG NQPQGPPPPP GKPQGPPPQG GNKPQGPPPP GKPQGPPPQG GSKSRSSRSP
   301  PGKPQGPPPQ GGNQPQGPPP PPGKPQGPPP QGGNKPQGPP PPGKPQGPPP QGGSKSRSAR
   361  SPPGKPQGPP QQEGNNPQGP PPPAGGNPQQ PQAPPAGQPQ GPPRPPQGGR PSRPPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.75
Highest tissue expression
11,382 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 11,382 nTPM
  • basal ganglia: 2.8 nTPM
  • cerebral cortex: 1.7 nTPM
  • bone marrow: 1.5 nTPM
  • hippocampal formation: 1.5 nTPM
  • skin: 1 nTPM

Single-cell type

  • salivary acinar cells: 1,688 nCPM
  • salivary myoepithelial cells: 409 nCPM
  • neutrophils: 74 nCPM
  • brain inhibitory neurons: 34 nCPM
  • brain excitatory neurons: 22 nCPM
  • innate lymphoid cells: 19 nCPM

Immune cell

  • myeloid DC: 0.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 35 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 21 nTPM
  • hippocampal formation: 20 nTPM
  • white matter: 12 nTPM
  • thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.97
gnomAD pLI
0
gnomAD missense Z
-3.9
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRB2 as an antibody target. Whether an autoantibody or antibody against PRB2 could matter depends on whether native PRB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRB2 is annotated as secreted, so native PRB2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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