Seroatlas · Human Serome Atlas

PRB1

Basic salivary proline-rich protein 1

Also known as: PRP1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P04280
Gene: PRB1
Canonical length: 392 aa
Protein class: Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for PRB1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

392 residues, UniProt reviewed canonical sequence.

>P04280|PRB1
     1  MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGPS PQGGNKPQGP PPPPGKPQGP
    61  PPQGGNKPQG PPPPGKPQGP PPQGDKSRSP RSPPGKPQGP PPQGGNQPQG PPPPPGKPQG
   121  PPPQGGNKPQ GPPPPGKPQG PPPQGDKSQS PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ
   181  GPPPQGGNKP QGPPPPGKPQ GPPPQGDKSQ SPRSPPGKPQ GPPPQGGNQP QGPPPPPGKP
   241  QGPPQQGGNR PQGPPPPGKP QGPPPQGDKS RSPQSPPGKP QGPPPQGGNQ PQGPPPPPGK
   301  PQGPPPQGGN KPQGPPPPGK PQGPPAQGGS KSQSARSPPG KPQGPPQQEG NNPQGPPPPA
   361  GGNPQQPQAP PAGQPQGPPR PPQGGRPSRP PQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.74
Highest tissue expression: 5,973 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 5,973 nTPM
lung: 5.9 nTPM
bone marrow: 1 nTPM
basal ganglia: 0.6 nTPM
skin: 0.6 nTPM
hippocampal formation: 0.2 nTPM

Single-cell type

salivary acinar cells: 1,821 nCPM
salivary myoepithelial cells: 574 nCPM
neutrophils: 95 nCPM
t-cells: 20 nCPM
salivary duct cells: 20 nCPM
monocytes: 15 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.4 nTPM
white matter: 0.4 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM
thalamus: 0.3 nTPM
cerebral cortex: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -4.03

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRB1 as an antibody target. Whether an autoantibody or antibody against PRB1 could matter depends on whether native PRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRB1 is annotated as secreted, so native PRB1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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