Seroatlas · Human Serome Atlas

PRAP1

Proline-rich acidic protein 1

Also known as: PRAP1_HUMAN, UPA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96NZ9
Gene
PRAP1
Ensembl
ENSG00000165828
Chromosome
10
Canonical length
151 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

151 residues, UniProt reviewed canonical sequence.

>Q96NZ9|PRAP1
     1  MRRLLLVTSL VVVLLWEAGA VPAPKVPIKM QVKHWPSEQD PEKAWGARVV EPPEKDDQLV
    61  VLFPVQKPKL LTTEEKPRGQ GRGPILPGTK AWMETEDTLG HVLSPEPDHD SLYHPPPEED
   121  QGEERPRLWV MPNHQVLLGP EEDQDHIYHP Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
1,069 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 1,069 nTPM
  • duodenum: 991 nTPM
  • liver: 718 nTPM
  • kidney: 166 nTPM
  • colon: 70 nTPM
  • choroid plexus: 57 nTPM

Single-cell type

  • enterocytes: 11,248 nCPM
  • colonocytes: 665 nCPM
  • paneth cells: 534 nCPM
  • enteric transient amplifying cells: 418 nCPM
  • hepatocytes: 331 nCPM
  • epididymal efferent duct absorptive cells: 194 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • basophil: 0.2 nTPM
  • memory B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • gdT-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • medulla oblongata: 4.9 nTPM
  • pons: 4.8 nTPM
  • white matter: 4.3 nTPM
  • midbrain: 4 nTPM
  • amygdala: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.26
gnomAD pLI
0.03
gnomAD missense Z
0.38
DepMap mean gene effect
0.19
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Proline-rich acidic protein 1
  • Proline-rich acidic protein 1, pregnancy-specific uterine

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAP1 as an antibody target. Whether an autoantibody or antibody against PRAP1 could matter depends on whether native PRAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAP1 is annotated as secreted, so native PRAP1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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