Seroatlas · Human Serome Atlas

PRAMEF33

PRAME family member 33

Also known as: PRA33_HUMAN, PRAMEF33P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0G2JMD5
Gene
PRAMEF33
Ensembl
ENSG00000237700
Chromosome
1
Canonical length
474 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

474 residues, UniProt reviewed canonical sequence.

>A0A0G2JMD5|PRAMEF33
     1  MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE ALKLMVQAWP
    61  FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL QVLDLQDVDE NFWTIWSGAR
   121  VLSCSPEAMS KRQTVEDCPR MGEHQPLKVF IDLCLKESTL DECLSYLFGW IHYRRGLVHL
   181  CCSKVQNYSM PTSSFRNLLE RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA
   241  FGYERELYVS VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF
   301  SDAYLADRDM ECLSQYPSLS QLKELRLIHI LMWTTNLQPL GALLEKVAAT LKTLVLKDCR
   361  IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH TRGLSKLGLE LYPAPLESLD
   421  YKGHVNWEIL TPIRAELMRT LREVRQPKRI FFGPVPCPTC GSWPSEKVDF HLCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAMEF33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
1 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAMEF33 as an antibody target. Whether an autoantibody or antibody against PRAMEF33 could matter depends on whether native PRAMEF33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAMEF33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAMEF33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRAMEF33. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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