Seroatlas · Human Serome Atlas

PRAMEF26

PRAME family member 26

Also known as: PRA26_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: H0Y7S4
Gene: PRAMEF26
Canonical length: 478 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for PRAMEF26 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>H0Y7S4|PRAMEF26
     1  MKMSIRTPPR LLELAGRSVL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA
    61  WPFRRLPLRP LIKMPCLETF QAVLNGLDAL LTHGVRPRRW KLQVLDLQDV CENFWMVWSE
   121  AMARGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEHLTCLL LWVKQRKDLL
   181  HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV
   241  LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
   301  LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
   361  DCGIIDSQVN AILPALSRCF ELNTFSFCGN PISMATLENL LSHTIILKNL CLELYPAPRE
   421  SYGADGTLCW SRFTQIRAEL MKRVRDLRHP KRILFGTDYC PDCGNRSFYD LEADQYCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAMEF26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.1 nTPM
cerebellum: 0.8 nTPM
cerebral cortex: 0.8 nTPM
white matter: 0.8 nTPM
basal ganglia: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.95
gnomAD pLI: 0
gnomAD missense Z: -1.35

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAMEF26 as an antibody target. Whether an autoantibody or antibody against PRAMEF26 could matter depends on whether native PRAMEF26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAMEF26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAMEF26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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