Seroatlas · Human Serome Atlas

PRAMEF25

PRAME family member 25

Also known as: PRA25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGN4
Gene
PRAMEF25
Ensembl
ENSG00000229571
Chromosome
1
Canonical length
478 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>A6NGN4|PRAMEF25
     1  MKMSIRTPPR LLELAGRSVL RDQALAMSTL EELPTELFPP LFMEAFSRRR CEALKLMVQA
    61  WPFRRLPLRP LIKMPCLETF QAVLNGLDAL LTHGVRPRRW KLQVLDLQDV CENFWMVWSE
   121  AMARGCFLNA KRNKKPVQDC PRMRGRQPLT VFVELWLKNR TLDEHLTCLL LWVKQRKDLL
   181  HLCCKKLKIL GMPFRNIRSI LKMVNLDCIQ EVEVNCKWVL PILTQFTPYL GHMRNLQKLV
   241  LSHMDVSRYV SPEQKKEIVT QFTTQFLKLH CLQKLYMNSV SFLEGHLDQL LSCLKTSLKV
   301  LTITNCVLLE SDLKHLSQCP SISQLKTLDL SGIRLTNYSL VPLQILLEKV AATLEYLDLD
   361  DCGIIDSQVN AILPALSRCF ELNTFSFCGN PISMATLENL LSHTIILKNL CLELYPAPRE
   421  SYGADGTLCW SRFTQIRAEL MKRVRDLRHP KRILFGTDYC PDCGNRSFYD LEADQYCC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAMEF25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM
  • blood vessel: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAMEF25 as an antibody target. Whether an autoantibody or antibody against PRAMEF25 could matter depends on whether native PRAMEF25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAMEF25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAMEF25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRAMEF25. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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