Seroatlas · Human Serome Atlas

PRAMEF19

PRAME family member 19

Also known as: PRA19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SWL8
Gene: PRAMEF19
Ensembl: ENSG00000204480
Chromosome: 1
Canonical length: 479 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q5SWL8|PRAMEF19
     1  MSFQAPRRLL ELAGQSLLRD QALAISVLDE LPRELFPRLF VEAFTSRCCE VLKVMVQAWP
    61  FPCLPLGSLM KTPDLEILHY VVDGIDCLLA QKVRPRRWKL QVLEMRDVDE NFWTIWSGAR
   121  PLSCSPEAMS KRQTVEDCPR TGEKQPLKVF MDVCLKEKSV DEDLSFFSGW VQHRRRSVHL
   181  CCTKVVNYSM NILNFRNILE TVYPDSIQVL EIWNMCWPCM VAEVSRYLSQ MKNLRKLFIS
   241  DGCGYLPSFE SQGQLVAEFS SVFLRLEYLQ MLYMRRIRFF EGYLDQLIRC LKSPLETLAL
   301  TYGSLDEEDL KCLPWYPSLS QLKQLNLSHG TLRFIRLEPL RALLEKVAAT LQTLFLVDCG
   361  IGDSKLRVIL PALSRCSNLT TFCFHGNDTS MDGLKDLLRH TGRLSNLSLE TYPAPRESLD
   421  NRGRVISELL TPLQAELMRI LREVREPNRI FFGPVSCPCC GMSPTEQLEF NFCLRGRPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAMEF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

differentiating spermatogonia: 0.1 nCPM
early spermatids: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1 nTPM
cerebral cortex: 1 nTPM
white matter: 1 nTPM
amygdala: 0.9 nTPM
basal ganglia: 0.9 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0.06
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.1
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAMEF19 as an antibody target. Whether an autoantibody or antibody against PRAMEF19 could matter depends on whether native PRAMEF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAMEF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAMEF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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