Seroatlas · Human Serome Atlas

PRADC1

Protease-associated domain-containing protein 1

Also known as: C2orf7, hPAP21, MGC13004, PADC1_HUMAN, PAP21

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BSG0
Gene
PRADC1
Ensembl
ENSG00000135617
Chromosome
2
Canonical length
188 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q9BSG0|PRADC1
     1  MVPGAAGWCC LVLWLPACVA AHGFRIHDYL YFQVLSPGDI RYIFTATPAK DFGGIFHTRY
    61  EQIHLVPAEP PEACGELSNG FFIQDQIALV ERGGCSFLSK TRVVQEHGGR AVIISDNAVD
   121  NDSFYVEMIQ DSTQRTADIP ALFLLGRDGY MIRRSLEQHG LPWAIISIPV NVTSIPTFEL
   181  LQPPWTFW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRADC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 119 nTPM
  • tongue: 100 nTPM
  • heart muscle: 96 nTPM
  • liver: 71 nTPM
  • choroid plexus: 62 nTPM
  • pancreas: 39 nTPM

Single-cell type

  • late spermatids: 257 nCPM
  • late primary spermatocytes: 141 nCPM
  • enterocytes: 88 nCPM
  • esophageal suprabasal cells: 84 nCPM
  • hepatocytes: 72 nCPM
  • megakaryocytes: 68 nCPM

Immune cell

  • non-classical monocyte: 106 nTPM
  • intermediate monocyte: 84 nTPM
  • plasmacytoid DC: 74 nTPM
  • total PBMC: 48 nTPM
  • NK-cell: 39 nTPM
  • myeloid DC: 36 nTPM

Brain region

  • choroid plexus: 39 nTPM
  • thalamus: 29 nTPM
  • cerebellum: 28 nTPM
  • basal ganglia: 26 nTPM
  • medulla oblongata: 25 nTPM
  • pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.53
gnomAD pLI
0
gnomAD missense Z
0.53
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRADC1 as an antibody target. Whether an autoantibody or antibody against PRADC1 could matter depends on whether native PRADC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRADC1 is annotated as secreted, so native PRADC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label PRADC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRADC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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