Seroatlas · Human Serome Atlas

PRAC2

Protein PRAC2

Also known as: C17orf93, HOXB-AS5, HOXB13-AS1, NCRNA00253, PRAC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
D3DTV9
Gene
PRAC2
Ensembl
ENSG00000229637
Chromosome
17
Canonical length
90 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

90 residues, UniProt reviewed canonical sequence.

>D3DTV9|PRAC2
     1  MDRRRMALRP GSRRPTAFFF HSRWLVPNLL AFFLGLSGAG PIHLPMPWPN GRRHRVLDPH
    61  TQLSTHEAPG RWKPVAPRTM KACPQVLLEW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 13 nTPM
  • rectum: 9 nTPM
  • colon: 4.3 nTPM
  • vagina: 2.5 nTPM
  • urinary bladder: 2.3 nTPM
  • cervix: 2.2 nTPM

Single-cell type

  • late spermatids: 74 nCPM
  • enteric transient amplifying cells: 53 nCPM
  • early spermatids: 42 nCPM
  • prostatic glandular cells: 25 nCPM
  • colonocytes: 22 nCPM
  • enteric stem cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAC2 as an antibody target. Whether an autoantibody or antibody against PRAC2 could matter depends on whether native PRAC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRAC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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