Seroatlas · Human Serome Atlas

PRAC1

Small nuclear protein PRAC1

Also known as: C17orf92, PRAC, PRAC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96KF2
Gene
PRAC1
Ensembl
ENSG00000159182
Chromosome
17
Canonical length
57 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

57 residues, UniProt reviewed canonical sequence.

>Q96KF2|PRAC1
     1  MLCAHFSDQG PAHLTTSKSA FLSNKKTSTL KHLLGETRSD GSACNSGISG GRGRKIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRAC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
193 nTPM

Expression across tissuesHPA

Tissue

  • rectum: 193 nTPM
  • prostate: 104 nTPM
  • colon: 99 nTPM
  • vagina: 13 nTPM
  • urinary bladder: 11 nTPM
  • cervix: 10 nTPM

Single-cell type

  • enteric stem cells: 658 nCPM
  • colonocytes: 608 nCPM
  • goblet cells: 596 nCPM
  • enteric transient amplifying cells: 553 nCPM
  • neuroendocrine cells: 397 nCPM
  • prostatic glandular cells: 181 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • medulla oblongata: 1.9 nTPM
  • white matter: 1.9 nTPM
  • cerebral cortex: 1.7 nTPM
  • cerebellum: 1.5 nTPM
  • hypothalamus: 1.5 nTPM
  • pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.93
gnomAD pLI
0.02
gnomAD missense Z
-0.33
DepMap mean gene effect
-0.45
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRAC1 as an antibody target. Whether an autoantibody or antibody against PRAC1 could matter depends on whether native PRAC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRAC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRAC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRAC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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