Seroatlas · Human Serome Atlas

PPWD1

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Also known as: KIAA0073, PPWD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BP3
Gene: PPWD1
Ensembl: ENSG00000113593
Chromosome: 5
Canonical length: 646 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nuclear body. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>Q96BP3|PPWD1
     1  MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW VGPLPVEATL
    61  AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK TDFIITASHD GHVKFWKKIE
   121  EGIEFVKHFR SHLGVIESIA VSSEGALFCS VGDDKAMKVF DVVNFDMINM LKLGYFPGQC
   181  EWIYCPGDAI SSVAASEKST GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR LNPVYKAVVS
   241  SDKSGMIEYW TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSVCFSP DGKKIATIGS
   301  DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL EKVDAVRLIN
   361  IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV MQLALFQGIA KKHRAATTIE
   421  MKASENPVLQ NIQADPTIVC TSFKKNRFYM FTKREPEDTK SADSDRDVFN EKPSKEEVMA
   481  ATQAEGPKRV SDSAIIHTSM GDIHTKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF
   541  MIQTGDPTGT GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP
   601  WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPWD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

thymus: 31 nTPM
lymph node: 28 nTPM
bone marrow: 26 nTPM
tonsil: 24 nTPM
spleen: 24 nTPM
ovary: 21 nTPM

Single-cell type

early spermatids: 121 nCPM
oligodendrocytes: 82 nCPM
somatotrophs: 77 nCPM
adrenal medulla cells: 75 nCPM
lactotrophs: 72 nCPM
t-cells: 71 nCPM

Immune cell

T-reg: 38 nTPM
naive CD4 T-cell: 36 nTPM
basophil: 35 nTPM
MAIT T-cell: 32 nTPM
eosinophil: 32 nTPM
naive CD8 T-cell: 31 nTPM

Brain region

white matter: 29 nTPM
cerebellum: 26 nTPM
basal ganglia: 21 nTPM
cerebral cortex: 20 nTPM
medulla oblongata: 20 nTPM
choroid plexus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.28
DepMap mean gene effect: -1.99
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

peptidyl-prolyl cis-trans isomerase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPWD1 as an antibody target. Whether an autoantibody or antibody against PPWD1 could matter depends on whether native PPWD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPWD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPWD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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