Seroatlas · Human Serome Atlas

PPT2

Lysosomal thioesterase PPT2

Also known as: PPT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UMR5
Gene: PPT2
Ensembl: ENSG00000221988
Chromosome: 6
Canonical length: 302 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the palmitoyl-protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream EGFL8 (EGF-like-domain, multiple 8) gene. [provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>Q9UMR5|PPT2
     1  MLGLCGQRLP AAWVLLLLPF LPLLLLAAPA PHRASYKPVI VVHGLFDSSY SFRHLLEYIN
    61  ETHPGTVVTV LDLFDGRESL RPLWEQVQGF REAVVPIMAK APQGVHLICY SQGGLVCRAL
   121  LSVMDDHNVD SFISLSSPQM GQYGDTDYLK WLFPTSMRSN LYRICYSPWG QEFSICNYWH
   181  DPHHDDLYLN ASSFLALING ERDHPNATVW RKNFLRVGHL VLIGGPDDGV ITPWQSSFFG
   241  FYDANETVLE MEEQLVYLRD SFGLKTLLAR GAIVRCPMAG ISHTAWHSNR TLYETCIEPW
   301  LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

ovary: 45 nTPM
cerebellum: 36 nTPM
skin: 29 nTPM
esophagus: 27 nTPM
cervix: 24 nTPM
kidney: 24 nTPM

Single-cell type

oligodendrocyte progenitor cells: 7.2 nCPM
oligodendrocytes: 7.1 nCPM
bergmann glia: 6.9 nCPM
ependymal cells: 6.9 nCPM
brain excitatory neurons: 6.7 nCPM
other brain neurons: 5.9 nCPM

Immune cell

naive CD8 T-cell: 1 nTPM
plasmacytoid DC: 0.7 nTPM
MAIT T-cell: 0.6 nTPM
memory CD4 T-cell: 0.2 nTPM
naive CD4 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM

Brain region

white matter: 0.8 nTPM
cerebral cortex: 0.6 nTPM
midbrain: 0.5 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.4 nTPM
cerebellum: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 2.05
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

fatty-acyl-CoA biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPT2 as an antibody target. Whether an autoantibody or antibody against PPT2 could matter depends on whether native PPT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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