PPP4R3C
Protein PPP4R3C
Also known as: FLFL3P, FLJ32867, P4R3C_HUMAN, PPP4R3CP, SMEK3P, smk1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZMV5
- Gene
- PPP4R3C
- Ensembl
- ENSG00000224960
- Chromosome
- X
- Canonical length
- 832 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to be located in nucleus. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
832 residues, UniProt reviewed canonical sequence.
>Q6ZMV5|PPP4R3C
1 MAGLRYSVKV YVLNEDEEWN NLGTGQVSST YDEQFQGMSL LVRSDSDGSV ILRSQIPPDR
61 PYGKYQETLI VWYEAENQGL VLKFQDPAGC QDIWKEICQA QGKDPSIQTT VNISDEPEED
121 FNEMSVISNM VVLPDCELNT LDQIADIVTS VFSSPVTDRE RLAEILKNEA YIPKLLQLFH
181 TCENLENTEG LHHLYEIIKG ILFLNEACLF EIMFSDECIM DVVGCLEYDP ALDQPKRHRD
241 FLTNDAKFKE VIPITNSELR QKIHQTYRLQ YIYDILLPVP SIFEDNFLST LTTFIFSNKA
301 EIVSMLQKDH KFLYEVFAQL KDETTHDDRR CELLFFFKEL CSFSQALQPQ SKDALFETLI
361 QLGVLPALKI VMIRDDLQVR SAAAVICAYL VEYSPSRIRE FIISEAHVCK DSDLFINVII
421 KQMICDTDPE LGGAVHLMVV LHTLLDPRNM LTTPEKSERS EFLHFFYKHC MHKFTAPLLA
481 ATSEHNCEED DIAGYDKSKN CPNDNQTAQL LALILELLTF CIQHHTFYIR SYILNKDLLR
541 KALILMNSKH THLILCVLRF MRRMICLNDE AYNNYIIKGN LFEPVVNALL DNGTRYNMLN
601 SAILELFEYI RVENIKPLVS HIVEKFYNTL ESIEYVQTFK GLKIKYEKER DRQSQIQKNL
661 HSVLQNIVVF RGTIEEIGLE EEICFMEDAG EVVMPPLEDD DEFMETKRTQ EGEAVMPPLE
721 DDDKFTETKR THQEGEAVMP PLEDDDEFME TKRNQEHEGK VDSPKRTSSG DFKFSSSYSA
781 CAAIGTGSPS GSSVVRLVDH PDDEEEKEED EEEKEEDKED ETSPKKKPHL SSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPP4R3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 1.8 nTPM
Expression across tissuesHPA
Tissue
- testis: 1.8 nTPM
- placenta: 0.2 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- early primary spermatocytes: 18 nCPM
- differentiating spermatogonia: 10 nCPM
- undifferentiated spermatogonia: 8.1 nCPM
- early spermatids: 1 nCPM
- late primary spermatocytes: 0.8 nCPM
- cytotrophoblasts: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about PPP4R3C.
Disease | ImmuneIEDB
Conditions an epitope on PPP4R3C was assayed in.
- colonic benign neoplasm T cell
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPP4R3C as an antibody target. Whether an autoantibody or antibody against PPP4R3C could matter depends on whether native PPP4R3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPP4R3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PPP4R3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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