Seroatlas · Human Serome Atlas

PPP4R1L

Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

Also known as: PP4RL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1A2
Gene: PPP4R1L
Canonical length: 415 aa

OverviewNCBI Gene

No narrative summary is available for PPP4R1L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q9P1A2|PPP4R1L
     1  MAEIPLYFVD LQDDLDDYGF EDYGTDCDNM RVTAFLDIPG QDNLPPLTRL EKYAFSENTF
    61  NRQIIARGLL DIFRDFGNNE EDFLTVMEIV VRLSEDAEPT VRTELMEQIP PIAIFLQENR
   121  SNFPVVLSEY LIPIVVRYLT DPNNQIICKM ASMLSKSTVE RLLLPRFCEL CGDRKLFQVR
   181  KVCAANFGDI CHAVGQEATE KFLIPKFFEL CSDAVWGMRK ACAECFTAVS HSSSPGVRRT
   241  QLFPLFIRLV SDPCRWVHQA AFQSLGPFTS TFANPSRAGL YLREDGALSI WPLTQDLDSG
   301  FASGSPAPSS GGNTSPASLT RSAKPVRSEP ELPVEGTSAK TSDCPHSSSS SDGPAESPVE
   361  SCVSAGAEWT RVSPETSACS KLSDMNDLPI SSYPGSDSWA CPGNTEDVFS HFLYW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP4R1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP4R1L as an antibody target. Whether an autoantibody or antibody against PPP4R1L could matter depends on whether native PPP4R1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP4R1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP4R1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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