Seroatlas · Human Serome Atlas

PPP3R2

Calcineurin subunit B type 2

Also known as: CANB2_HUMAN, PPP3RL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LZ3
Gene: PPP3R2
Ensembl: ENSG00000188386
Chromosome: 9
Canonical length: 170 aa
Protein class: FDA approved drug targets, Predicted intracellular proteins
Subcellular location: Plasma membrane,Primary cilium,Cytosol

OverviewNCBI Gene

Enables calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in cytosol. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>Q96LZ3|PPP3R2
     1  MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR HNPLVRRVID
    61  VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD MDKDGYISNG ELFQVLKMMV
   121  GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF EEFSAVVRDL EIHKKLVLIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP3R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

testis: 76 nTPM
skeletal muscle: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 3.8 nCPM
late spermatids: 1.8 nCPM
early spermatids: 1.5 nCPM
sertoli cells: 0.3 nCPM
early primary spermatocytes: 0.2 nCPM
differentiating spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 2.6 nTPM
pons: 2.4 nTPM
basal ganglia: 2.2 nTPM
hypothalamus: 2.2 nTPM
midbrain: 1.7 nTPM
medulla oblongata: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP3R2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SPATA33

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP3R2 as an antibody target. Whether an autoantibody or antibody against PPP3R2 could matter depends on whether native PPP3R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP3R2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP3R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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