Seroatlas · Human Serome Atlas

PPP1R3G

Protein phosphatase 1 regulatory subunit 3G

Also known as: PP13G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B7ZBB8
Gene: PPP1R3G
Ensembl: ENSG00000219607
Chromosome: 6
Canonical length: 358 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable glycogen binding activity and protein phosphatase 1 binding activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glucose homeostasis; positive regulation of glycogen (starch) synthase activity; and positive regulation of glycogen biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>B7ZBB8|PPP1R3G
     1  MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP DAQLGDRPLS
    61  PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ QQQQQAVALG GEGAEDAQLG
   121  PGGCCAKCKK RVQFADTLGL SLASVKHFSE AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL
   181  LAAAAVAAPL SAPPSRLRPL FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL
   241  SCPGPRAVTV RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF
   301  HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR YARPADAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 6 nTPM

Expression across tissuesHPA

Tissue

liver: 6 nTPM
heart muscle: 5.6 nTPM
basal ganglia: 4.3 nTPM
amygdala: 3.4 nTPM
cerebral cortex: 3.4 nTPM
blood vessel: 3.2 nTPM

Single-cell type

esophageal apical cells: 67 nCPM
kupffer cells: 11 nCPM
endometrial glandular cells: 11 nCPM
hofbauer cells: 8.7 nCPM
hepatic stellate cells: 6.5 nCPM
esophageal suprabasal cells: 5.6 nCPM

Immune cell

non-classical monocyte: 0.8 nTPM
myeloid DC: 0.7 nTPM
classical monocyte: 0.5 nTPM
intermediate monocyte: 0.3 nTPM
total PBMC: 0.2 nTPM
basophil: 0.1 nTPM

Brain region

cerebral cortex: 5.8 nTPM
amygdala: 5.2 nTPM
midbrain: 5.2 nTPM
medulla oblongata: 5 nTPM
thalamus: 4.9 nTPM
basal ganglia: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

protein phosphatase type 1 complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Phosphoprotein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R3G as an antibody target. Whether an autoantibody or antibody against PPP1R3G could matter depends on whether native PPP1R3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R3G is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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