PPP1R3F

Protein identityUniProt · HPA

UniProt accession

Q6ZSY5

Gene

PPP1R3F

Ensembl

ENSG00000049769

Chromosome

X

Canonical length

799 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

799 residues, UniProt reviewed canonical sequence.

>Q6ZSY5|PPP1R3F
     1  MARTAPVEPP LRHSAPPSPA AGEPRTSVEA AVAPRRVLFA DEALGLPLAQ LRRYRPWGGP
    61  GAGKMAAAAG QDGGGGGGAD EDDDGEDGDE GEEEEEACPE PSPLCPVPAG GGFYLVPTFS
   121  LPPAPGRLER LGRVMVELEA LLPPPGAVPG GAGVWVPGGR PPVLRGLVRV LNRSFEKAVH
   181  VRASHDGWAS FCDHPARYVP RSPPWAGAGG TGAGDPILDP GLGLGPGQAS ASSPDDGGRT
   241  DRFAFQLPFA EGAGDGARLD FVVRYETPEG TFWANNHGRN YTVLLRIAPA PTPTDAEGLP
   301  QQQQLPQLEP QPECQGPVEA EARQLKSCMK PVRRRPAEEE LKTKNMDDNT FAMAEHPDVQ
   361  ESVGPLVAPT PLRPWPQMTL QVSDVPMTGN PAEEGDVPRS SPPVAFTEVL QAPAIRIPPS
   421  SPLCGLGGSP RDQASGPDAS EGATGPFLEP SQQQAEATWG VSSENGGGLE AVSGSEELLG
   481  EDTIDQELEQ LYLSHLSRLR AAVAAGGAGG GGEGSTDGGM SPSHPLGILT DRDLILKWPG
   541  PERALNSALA EEITLHYARL GRGVELIKDT EDPDDEGEGE EGLSVTPSSP EGDSPKESPP
   601  EILSGARSVV ATMGDVWLPW AEGSGCDGPV VLGTEGQFIG DPEKGMGKDT SSLHMNRVIA
   661  GVTESLGEAG TEAQIEVTSE WAGSLDPISG KEPASPVLLQ GQNPTLLSPL GAEVCLSSVA
   721  RPHVSSQDEK DAGPSLEPPK KSPTLAVPAE CVCALPPQLR GPLTQTLGVL AGLVVVPVAL
   781  NSGVSLLVLA LCLSLAWFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP1R3F.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 176 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• PPP1R3F-related neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

0.21

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of glycogen biosynthetic process
• regulation of glycogen (starch) synthase activity

Molecular functions

• glycogen binding
• protein phosphatase 1 binding
• protein phosphatase binding

Cellular components

• membrane
• protein phosphatase type 1 complex

Protein domainsUniProt · Pfam · InterPro

• CBM21 (carbohydrate binding type-21) domain
• CBM21 domain superfamily
• Protein phosphatase 1 regulatory subunit 3
• Carbohydrate/starch-binding module (family 21)

KeywordsUniProt

• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix