Seroatlas · Human Serome Atlas

PPP1R3E

Protein phosphatase 1 regulatory subunit 3E

Also known as: FLJ00089, PPR3E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7J1
Gene: PPP1R3E
Ensembl: ENSG00000235194
Chromosome: 14
Canonical length: 279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Mitotic spindle,Mitochondria

OverviewNCBI Gene

Predicted to enable [phosphorylase] phosphatase activity; glycogen binding activity; and protein phosphatase 1 binding activity. Predicted to be involved in positive regulation of glycogen biosynthetic process. Predicted to be located in glycogen granule. Predicted to be part of protein phosphatase type 1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>Q9H7J1|PPP1R3E
     1  MSRERPPGTD IPRNLSFIAA LTERAYYRSQ RPSLEEEPEE EPGEGGTRFG ARSRAHAPSR
    61  GRRARSAPAG GGGARAPRSR SPDTRKRVRF ADALGLELAV VRRFRPGELP RVPRHVQIQL
   121  QRDALRHFAP CQPRARGLQE ARAALEPASE PGFAARLLTQ RICLERAEAG PLGVAGSARV
   181  VDLAYEKRVS VRWSADGWRS QREAPAAYAG PAPPPPRADR FAFRLPAPPI GGALLFALRY
   241  RVTGHEFWDN NGGRDYALRG PEHPGSGGAP EPQGWIHFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

retina: 43 nTPM
cerebellum: 35 nTPM
midbrain: 23 nTPM
spinal cord: 22 nTPM
cerebral cortex: 19 nTPM
pituitary gland: 19 nTPM

Single-cell type

early spermatids: 105 nCPM
adrenal cortex cells: 73 nCPM
late spermatids: 60 nCPM
retinal bipolar cells: 48 nCPM
oligodendrocytes: 44 nCPM
cone photoreceptor cells: 39 nCPM

Immune cell

non-classical monocyte: 1.8 nTPM
intermediate monocyte: 1.4 nTPM
memory B-cell: 1 nTPM
MAIT T-cell: 0.6 nTPM
naive B-cell: 0.6 nTPM
gdT-cell: 0.5 nTPM

Brain region

white matter: 39 nTPM
pons: 32 nTPM
medulla oblongata: 29 nTPM
cerebellum: 29 nTPM
thalamus: 28 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.39
gnomAD pLI: 0.24
gnomAD missense Z: 0.62
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R3E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R3E as an antibody target. Whether an autoantibody or antibody against PPP1R3E could matter depends on whether native PPP1R3E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R3E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R3E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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