PPP1R3D

Protein identityUniProt · HPA

UniProt accession

O95685

Gene

PPP1R3D

Ensembl

ENSG00000132825

Chromosome

20

Canonical length

299 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli,Vesicles,Mitochondria,Cytosol,Calyx,Connecting piece,Flagellar centriole,Mid piece,Principal piece

OverviewNCBI Gene

Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>O95685|PPP1R3D
     1  MSRGPSSAVL PSALGSRKLG PRSLSCLSDL DGGVALEPRA CRPPGSPGRA PPPTPAPSGC
    61  DPRLRPIILR RARSLPSSPE RRQKAAGAPG AACRPGCSQK LRVRFADALG LELAQVKVFN
   121  AGDDPSVPLH VLSRLAINSD LCCSSQDLEF TLHCLVPDFP PPVEAADFGE RLQRQLVCLE
   181  RVTCSDLGIS GTVRVCNVAF EKQVAVRYTF SGWRSTHEAV ARWRGPAGPE GTEDVFTFGF
   241  PVPPFLLELG SRVHFAVRYQ VAGAEYWDNN DHRDYSLTCR NHALHMPRGE CEESWIHFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

9.1 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.53

gnomAD pLI

0

gnomAD missense Z

0.58

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycogen metabolic process
• regulation of glycogen biosynthetic process
• regulation of glycogen catabolic process

Molecular functions

• glycogen binding
• protein phosphatase 1 binding
• protein serine/threonine phosphatase activity

Cellular components

• glycogen granule
• protein phosphatase type 1 complex

Protein domainsUniProt · Pfam · InterPro

• CBM21 (carbohydrate binding type-21) domain
• Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
• CBM21 domain superfamily
• Protein phosphatase 1 regulatory subunit 3
• Carbohydrate/starch-binding module (family 21)

KeywordsUniProt

• Carbohydrate metabolism
• Glycogen metabolism
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PPP1R3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPM2A
• PPP1CA