Seroatlas · Human Serome Atlas

PPP1R37

Protein phosphatase 1 regulatory subunit 37

Also known as: LRRC68, PPR37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75864
Gene: PPP1R37
Ensembl: ENSG00000104866
Chromosome: 19
Canonical length: 691 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable protein phosphatase inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>O75864|PPP1R37
     1  MEIAPQEAPP VPGADGDIEE APAEAGSPSP ASPPADGRLK AAAKRVTFPS DEDIVSGAVE
    61  PKDPWRHAQN VTVDEVIGAY KQACQKLNCR QIPKLLRQLQ EFTDLGHRLD CLDLKGEKLD
   121  YKTCEALEEV FKRLQFKVVD LEQTNLDEDG ASALFDMIEY YESATHLNIS FNKHIGTRGW
   181  QAAAHMMRKT SCLQYLDARN TPLLDHSAPF VARALRIRSS LAVLHLENAS LSGRPLMLLA
   241  TALKMNMNLR ELYLADNKLN GLQDSAQLGN LLKFNCSLQI LDLRNNHVLD SGLAYICEGL
   301  KEQRKGLVTL VLWNNQLTHT GMAFLGMTLP HTQSLETLNL GHNPIGNEGV RHLKNGLISN
   361  RSVLRLGLAS TKLTCEGAVA VAEFIAESPR LLRLDLRENE IKTGGLMALS LALKVNHSLL
   421  RLDLDREPKK EAVKSFIETQ KALLAEIQNG CKRNLVLARE REEKEQPPQL SASMPETTAT
   481  EPQPDDEPAA GVQNGAPSPA PSPDSDSDSD SDGEEEEEEE GERDETPCPA LVPPTDSLGP
   541  GDRSPPGSPS TPTEQRISVS SPGRGHKVFV VTRVESPPER AEPPASPTPP SPPPPPSPPA
   601  SPSLPPAGAI DTRDTGSSEP QPPPEPPRSG PPLPNGLKPE FALALPPEPP PGPEVKGGSC
   661  GLEHELSCSK NEKELEELLL EASQESGQET L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 41 nTPM
cerebellum: 39 nTPM
cerebral cortex: 31 nTPM
stomach: 30 nTPM
adrenal gland: 28 nTPM
urinary bladder: 23 nTPM

Single-cell type

retinal horizontal cells: 4 nCPM
epicardial cells: 2.3 nCPM
urothelial cells: 2.2 nCPM
cone photoreceptor cells: 2.1 nCPM
respiratory deuterosomal cells: 2.1 nCPM
conjunctival goblet cells: 1.9 nCPM

Immune cell

memory B-cell: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 48 nTPM
hippocampal formation: 42 nTPM
amygdala: 42 nTPM
white matter: 39 nTPM
basal ganglia: 37 nTPM
cerebellum: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.99
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.13
DepMap dependency class: selective

OntologyGO

Molecular functions

protein phosphatase inhibitor activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R37 as an antibody target. Whether an autoantibody or antibody against PPP1R37 could matter depends on whether native PPP1R37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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