Seroatlas · Human Serome Atlas

PPP1R36

Protein phosphatase 1 regulatory subunit 36

Also known as: C14orf50, PPR36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LQ0
Gene: PPP1R36
Ensembl: ENSG00000165807
Chromosome: 14
Canonical length: 422 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q96LQ0|PPP1R36
     1  MYRVPEFYAR RKRLGGQTPY LMDQLGLRLG MWYWKDETRT LEFRRFAAED SVQWLLKHHP
    61  HFTPAAEVKE KGKKGKAVHF AETDGPASDR LTDKRLAAKD DKSAKAVEKR GQQGTITLDD
   121  VKFVTLLLLQ DTEMQRICSF TTFMRNKNLD NFLMALLYYL SHYLEKNSLE KKPKSYMVGL
   181  VEKKEMELVL SELEAAQRYL AQKYCILVLG LAVPDKHHMC CGKEKISDTQ KDWKFFESFY
   241  TFCTYVAWIV FRRQHLTEIE EEVGRLFRTN MFNIPRRRRE DEESGGEKKR MTFVQFRRMM
   301  AKRPAIKKAI NMRSPVMSTL LPSLREKAQN VFEKKYHQVD VRFPAEMQKH VGTLDSVPMP
   361  VVGILGEPRC LFNPHTLHPL DPEENTKSFG RYPSLMENNN MRIQDTLDLV MKTLSSHTSC
   421  PK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

testis: 35 nTPM
fallopian tube: 12 nTPM
pancreas: 10 nTPM
stomach: 6.8 nTPM
duodenum: 6.2 nTPM
colon: 6.1 nTPM

Single-cell type

late spermatids: 1,275 nCPM
late primary spermatocytes: 390 nCPM
early spermatids: 322 nCPM
fallopian tube ciliated cells: 115 nCPM
respiratory ciliated cells: 74 nCPM
pdcs: 62 nCPM

Immune cell

memory CD8 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
memory CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

white matter: 4.2 nTPM
pons: 3.8 nTPM
medulla oblongata: 3.4 nTPM
spinal cord: 3.3 nTPM
midbrain: 2.9 nTPM
basal ganglia: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: 0.16
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Protein phosphatase 1 regulatory subunit 36
Protein phosphatase 1 inhibitor

KeywordsUniProt

Protein phosphatase inhibitor

InteractionsUniProt · HPA

Protein binding partners of PPP1R36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PPP1CA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R36 as an antibody target. Whether an autoantibody or antibody against PPP1R36 could matter depends on whether native PPP1R36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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