Seroatlas · Human Serome Atlas

PPP1R35

Protein phosphatase 1 regulatory subunit 35

Also known as: C7orf47, MGC22793, PPR35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAP8
Gene: PPP1R35
Ensembl: ENSG00000160813
Chromosome: 7
Canonical length: 253 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable phosphatase binding activity and protein phosphatase inhibitor activity. Involved in positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q8TAP8|PPP1R35
     1  MMMGCGESEL KSADGEEAAA VPGPPPEPQV PQLRAPVPEP GLDLSLSPRP DSPQPRHGSP
    61  GRRKGRAERR GAARQRRQVR FRLTPPSPVR SEPQPAVPQE LEMPVLKSSL ALGLELRAAA
   121  GSHFDAAKAV EEQLRKSFQI RCGLEESVSE GLNVPRSKRL FRDLVSLQVP EEQVLNAALR
   181  EKLALLPPQA RAPHPKEPPG PGPDMTILCD PETLFYESPH LTLDGLPPLR LQLRPRPSED
   241  TFLMHRTLRR WEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

testis: 51 nTPM
spleen: 25 nTPM
adrenal gland: 19 nTPM
choroid plexus: 17 nTPM
cerebellum: 16 nTPM
liver: 15 nTPM

Single-cell type

late primary spermatocytes: 120 nCPM
cytotrophoblasts: 80 nCPM
platelets: 75 nCPM
migrating cytotrophoblasts: 72 nCPM
early primary spermatocytes: 66 nCPM
esophageal basal cells: 62 nCPM

Immune cell

basophil: 17 nTPM
neutrophil: 11 nTPM
T-reg: 7.7 nTPM
plasmacytoid DC: 7.6 nTPM
memory CD8 T-cell: 6.6 nTPM
MAIT T-cell: 6.2 nTPM

Brain region

cerebellum: 12 nTPM
choroid plexus: 10 nTPM
thalamus: 9.5 nTPM
medulla oblongata: 9.4 nTPM
spinal cord: 9.2 nTPM
hypothalamus: 8.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP1R35.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Progressive microcephaly

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.01
gnomAD missense Z: -0.05
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein phosphatase 1 regulatory subunit 35, C-terminal
Protein phosphatase 1 regulatory subunit 35
Protein phosphatase 1 regulatory subunit 35 C-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R35 as an antibody target. Whether an autoantibody or antibody against PPP1R35 could matter depends on whether native PPP1R35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R35 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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