Seroatlas · Human Serome Atlas

PPP1R2C

Protein phosphatase inhibitor 2 family member C

Also known as: I-4, IPP2C_HUMAN, PPP1R2P9

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14990
Gene
PPP1R2C
Ensembl
ENSG00000102055
Chromosome
X
Canonical length
202 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>O14990|PPP1R2C
     1  MSASTSSHRP IKGILKNKSS SGSSVATSGQ QSGGTIQDVK RKKSQKWDES SILAAHRATY
    61  RDYDLMKANE PGTSYMSVQD NGEDSVRDVE GEDSVRGVEG KEATDASDHS CEVDEQESSE
   121  AYMRKILLHK QEKKRQFEMR RRLHYNEELN IKLARQLMWK ELQSEDNENE ETPQGTNEEK
   181  TAAEESEEAP LTGGLQTQSC DP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • testis: 76 nTPM
  • retina: 0.3 nTPM
  • thymus: 0.2 nTPM
  • tonsil: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 826 nCPM
  • late spermatids: 658 nCPM
  • late primary spermatocytes: 344 nCPM
  • plasma cells: 58 nCPM
  • t-cells: 21 nCPM
  • early primary spermatocytes: 18 nCPM

Immune cell

  • T-reg: 0.5 nTPM
  • memory B-cell: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R2C as an antibody target. Whether an autoantibody or antibody against PPP1R2C could matter depends on whether native PPP1R2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1R2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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