PPP1R27
Protein phosphatase 1 regulatory subunit 27
Also known as: DYSFIP1, PPR27_HUMAN, toonin
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86WC6
- Gene
- PPP1R27
- Ensembl
- ENSG00000182676
- Chromosome
- 17
- Canonical length
- 154 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Enables phosphatase binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>Q86WC6|PPP1R27
1 MPSRTARYAR YSPRQRRRRM LADRSVRFPN DVLFLDHIRQ GDLEQVGRFI RTRKVSLATI
61 HPSGLAALHE AVLSGNLECV KLLVKYGADI HQRDEAGWTP LHIACSDGYP DIARYLISLG
121 ADRDATNDDG DLPSDLIDPD YKELVELFKG TTMDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPP1R27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 1,144 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 1,144 nTPM
- tongue: 44 nTPM
- pituitary gland: 11 nTPM
- salivary gland: 7.1 nTPM
- prostate: 1.5 nTPM
- bone marrow: 1.2 nTPM
Single-cell type
- thymic myoid cells: 11 nCPM
- late primary spermatocytes: 9.9 nCPM
- early spermatids: 5.4 nCPM
- myonuclei: 5.2 nCPM
- gonadotrophs: 3.6 nCPM
- migrating cytotrophoblasts: 1.4 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- basophil: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 1.1 nTPM
- cerebellum: 1 nTPM
- white matter: 1 nTPM
- basal ganglia: 0.8 nTPM
- hippocampal formation: 0.8 nTPM
- medulla oblongata: 0.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.8
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.26
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Ankyrin repeat
- Ankyrin repeat-containing domain superfamily
- Ankyrin repeats (3 copies)
- Protein phosphatase 1 regulatory subunit 27
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PPP1R27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPP1R27 as an antibody target. Whether an autoantibody or antibody against PPP1R27 could matter depends on whether native PPP1R27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPP1R27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PPP1R27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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