Seroatlas · Human Serome Atlas

PPP1R26

Protein phosphatase 1 regulatory subunit 26

Also known as: KIAA0649, PPR26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T8A7
Gene: PPP1R26
Ensembl: ENSG00000196422
Chromosome: 9
Canonical length: 1209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable protein phosphatase inhibitor activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1209 residues, UniProt reviewed canonical sequence.

>Q5T8A7|PPP1R26
     1  MFLMNASPVV ALQSKWEAFG PPGSCRFPRC FSEADEGVES ASVSARVQML ISTLQRDGAA
    61  RGTSDERAAQ RGHRAEGCHD ARPAAKPTVH KEPPALAVCG LVADFDPMGE EETTDFGPLV
   121  LDSDSDDSVD RDIEEAIQEY LKAKSGAAQP GAGGAQPGAA QPSRAAGGGS RCKPEPAHGS
   181  APTALCPPKL VPGSGGGPGS QVGSSKDQGS ASPVSVSSDD SFEQSIRAEI EQFLNEKRQH
   241  ETQKCDGSVE KKPDTNENSA KSLLKSHQEP PTKVVHRQGL LGVQKEFAFR KPPRLAKMNV
   301  QPRSLRSKVT TTQENEGSTK PATPCRPSEA AQNKGGIKRS ASAARRGKRV MSAAQASEAS
   361  DSSSDDGIEE AIQLYQLQKT RKEADGDLPQ RVQLREERAP DPPAHSTSSA TKSALPETHR
   421  KTPSKKKLVA TKTMDPGPGG LDTDHAPKLL KETKAPPPAS PASRSEFVER SSCRADTSAE
   481  LMCAEAILDI SKTILPAPVE GSDGSLSASP LFYSPNVPSR SDGDSSSVDS DDSIEQEIRT
   541  FLALKAQSGS LLARGESCPQ AAQGPLLPPG LNSQTGGHKT PLSKTPDPLL GCKRKRRGGG
   601  HVRPSTPKKM QEVVKDGSQD ADHSQGRAEP GHERRDLPIQ GKASEALGGE GTARGPGDTR
   661  MSQGQGKTDE ARRLDEKESS EDKSSSLDSD EDLDTAIKDL LRSKRKLKKR CREPRAACRK
   721  KVRFSTAQTH FLEQLGGLRR DWKDRGPPVL KSCLSKSKRD SGEGPGKKPP SVFGSTAERM
   781  RQEGAASQDA ALAFRVRRPA SASASEGNPF PRESQGPAPS PGSLSDDSSS VDSNDSIELE
   841  IRKFLAEKAK ESVSSSEVQA EGPTALGTGG PARPEVLCRK EPAPPPGVCT RSQRARGVPH
   901  LAEGLRGTES AGAQGTAGLF SQGGKGLPAA PARGDPVPPR STSGGVSAKG LSVSRRNVYV
   961  HKDQSPRGAE PAAKSAFGQL PSCATAGTEA GGARGTFHMG CGSPSFLTPS PGAERDAGAQ
  1021  ADRTPPWSDF AHQSRLPSPW VLRSEGRDAV WRGGVGSERD KGSEGPARGL PSLPLAGFSP
  1081  LLSTQLFHFG KGVSWGGRQA GLFSPHLGLP LQGPSFSAFR EAQAGPSPVF GSPHLLAKKD
  1141  GGPWPTRKAQ AGLSLHDRRS SGSEESILDL RYRRRVNRDD QEQDALGSDA SDFSDTSTED
  1201  SGGSSVVKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 19 nTPM
amygdala: 17 nTPM
pituitary gland: 15 nTPM
hippocampal formation: 14 nTPM
parathyroid gland: 14 nTPM
basal ganglia: 13 nTPM

Single-cell type

cholangiocytes: 22 nCPM
alveolar cells type 1: 21 nCPM
proximal tubule cells: 18 nCPM
breast lactating cells: 15 nCPM
gonadotrophs: 14 nCPM
salivary duct cells: 14 nCPM

Immune cell

eosinophil: 0.8 nTPM
NK-cell: 0.7 nTPM
myeloid DC: 0.4 nTPM
classical monocyte: 0.3 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM

Brain region

hypothalamus: 23 nTPM
hippocampal formation: 23 nTPM
cerebral cortex: 22 nTPM
amygdala: 22 nTPM
midbrain: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.07
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein phosphatase inhibitor activity

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

Protein phosphatase 1 regulatory subunit 26
Protein phosphatase 1 regulatory subunit 26, N-terminal domain
Protein phosphatase 1 regulatory subunit 26 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R26 as an antibody target. Whether an autoantibody or antibody against PPP1R26 could matter depends on whether native PPP1R26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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