Seroatlas · Human Serome Atlas

PPP1R1C

Protein phosphatase 1 regulatory subunit 1C

Also known as: Inhibitor-1-like, PPR1C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVI7
Gene: PPP1R1C
Ensembl: ENSG00000150722
Chromosome: 2
Canonical length: 109 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Golgi apparatus

OverviewNCBI Gene

Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

109 residues, UniProt reviewed canonical sequence.

>Q8WVI7|PPP1R1C
     1  MEPNSPKKIQ FAVPVFQSQI APEAAEQIRK RRPTPASLVI LNEHNPPEID DKRGPNTQGE
    61  LQNASPKQRK QSVYTPPTIK GVKHLKGQNE SAFPEEEEGT NEREEQRDH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 22 nTPM
tongue: 4.8 nTPM
skeletal muscle: 3.6 nTPM
retina: 3.2 nTPM
prostate: 1.4 nTPM
liver: 1 nTPM

Single-cell type

late primary spermatocytes: 412 nCPM
late spermatids: 340 nCPM
cardiomyocytes: 304 nCPM
retinal ganglion cells: 224 nCPM
myonuclei: 192 nCPM
gonadotrophs: 171 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 5.8 nTPM
hypothalamus: 5.2 nTPM
cerebellum: 3.8 nTPM
choroid plexus: 3.2 nTPM
midbrain: 3 nTPM
medulla oblongata: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein phosphatase inhibitor activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R1C as an antibody target. Whether an autoantibody or antibody against PPP1R1C could matter depends on whether native PPP1R1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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