Seroatlas · Human Serome Atlas

PPP1R1B

Protein phosphatase 1 regulatory subunit 1B

Also known as: DARPP-32, FLJ20940, PPR1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UD71
Gene: PPP1R1B
Ensembl: ENSG00000131771
Chromosome: 17
Canonical length: 204 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q9UD71|PPP1R1B
     1  MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE ASPHQRASGE
    61  GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ ASEEEDELGE LRELGYPREE
   121  DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG QKTTCGQGLE GPWERPPPLD ESERDGGSED
   181  QVEDPALSEP GEEPQRPSPS EPGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 1,464 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 1,464 nTPM
basal ganglia: 1,369 nTPM
salivary gland: 346 nTPM
cerebral cortex: 281 nTPM
amygdala: 252 nTPM
midbrain: 224 nTPM

Single-cell type

enteric stem cells: 458 nCPM
prostatic club cells: 451 nCPM
enteric transient amplifying cells: 352 nCPM
paneth cells: 259 nCPM
lacrimal acinar cells: 239 nCPM
gastric progenitor cells: 227 nCPM

Immune cell

eosinophil: 1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 1,134 nTPM
choroid plexus: 709 nTPM
medulla oblongata: 325 nTPM
thalamus: 306 nTPM
amygdala: 235 nTPM
midbrain: 225 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.24
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R1B as an antibody target. Whether an autoantibody or antibody against PPP1R1B could matter depends on whether native PPP1R1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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