Seroatlas · Human Serome Atlas

PPP1R17

Protein phosphatase 1 regulatory subunit 17

Also known as: C7orf16, GSBS, PPR17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O96001
Gene: PPP1R17
Ensembl: ENSG00000106341
Chromosome: 7
Canonical length: 155 aa
Protein class: Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>O96001|PPP1R17
     1  MMSTEQMQPL ELSEDRLDKL DPRCSHLDDL SDQFIKDCDL KKKPRKGKNV QATLNVESDQ
    61  KKPRRKDTPA LHIPPFIPGV FSEHLIKRYD VQERHPKGKM IPVLHNTDLE QKKPRRKDTP
   121  ALHMSPFAAG VTLLRDERPK AIVEDDEKDG DKIAI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 22 nTPM
hypothalamus: 11 nTPM
adrenal gland: 4.3 nTPM
pituitary gland: 3.1 nTPM
midbrain: 2 nTPM
cerebral cortex: 1.9 nTPM

Single-cell type

late spermatids: 179 nCPM
early spermatids: 64 nCPM
cardiomyocytes: 49 nCPM
adrenal medulla cells: 21 nCPM
corticotrophs: 19 nCPM
other brain neurons: 11 nCPM

Immune cell

non-classical monocyte: 52 nTPM
intermediate monocyte: 12 nTPM
myeloid DC: 2.4 nTPM
total PBMC: 0.8 nTPM
naive B-cell: 0.3 nTPM
classical monocyte: 0.1 nTPM

Brain region

cerebellum: 41 nTPM
thalamus: 35 nTPM
midbrain: 21 nTPM
amygdala: 19 nTPM
hypothalamus: 18 nTPM
cerebral cortex: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.56
gnomAD pLI: 0
gnomAD missense Z: -0.02
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein serine/threonine phosphatase inhibitor activity

Protein domainsUniProt · Pfam · InterPro

Protein phosphatase 1 regulatory subunit 17

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R17 as an antibody target. Whether an autoantibody or antibody against PPP1R17 could matter depends on whether native PPP1R17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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