Seroatlas · Human Serome Atlas

PPP1R14D

Protein phosphatase 1 regulatory subunit 14D

Also known as: CPI17-like, FLJ20251, GBPI-1, MGC119014, MGC119016, PP14D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXH3
Gene: PPP1R14D
Ensembl: ENSG00000166143
Chromosome: 15
Canonical length: 145 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]

Canonical amino-acid sequenceUniProt

145 residues, UniProt reviewed canonical sequence.

>Q9NXH3|PPP1R14D
     1  MLSSSPASCT SPSPDGENPC KKVHWASGRR RTSSTDSESK SHPDSSKIPR SRRPSRLTVK
    61  YDRGQLQRWL EMEQWVDAQV QELFQDQATP SEPEIDLEAL MDLSTEEQKT QLEAILGNCP
   121  RPTEAFISEL LSQLKKLRRL SRPQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R14D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 105 nTPM

Expression across tissuesHPA

Tissue

duodenum: 105 nTPM
colon: 100 nTPM
rectum: 87 nTPM
small intestine: 78 nTPM
gallbladder: 15 nTPM
appendix: 9.1 nTPM

Single-cell type

enterocytes: 378 nCPM
colonocytes: 288 nCPM
enteric transient amplifying cells: 104 nCPM
enteric stem cells: 72 nCPM
paneth cells: 62 nCPM
goblet cells: 48 nCPM

Immune cell

non-classical monocyte: 0.3 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 1.8 nTPM
midbrain: 1.2 nTPM
cerebral cortex: 1 nTPM
medulla oblongata: 1 nTPM
pons: 1 nTPM
white matter: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein serine/threonine phosphatase inhibitor activity

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R14D as an antibody target. Whether an autoantibody or antibody against PPP1R14D could matter depends on whether native PPP1R14D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R14D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R14D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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