PPP1R14C
Protein phosphatase 1 regulatory subunit 14C
Also known as: CPI17-like, KEPI, NY-BR-81, PP14C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TAE6
- Gene
- PPP1R14C
- Ensembl
- ENSG00000198729
- Chromosome
- 6
- Canonical length
- 165 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
Canonical amino-acid sequenceUniProt
165 residues, UniProt reviewed canonical sequence.
>Q8TAE6|PPP1R14C
1 MSVATGSSET AGGASGGGAR VFFQSPRGGA GGSPGSSSGS GSSREDSAPV ATAAAAGQVQ
61 QQQQRRHQQG KVTVKYDRKE LRKRLVLEEW IVEQLGQLYG CEEEEMPEVE IDIDDLLDAD
121 SDEERASKLQ EALVDCYKPT EEFIKELLSR IRGMRKLSPP QKKSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PPP1R14C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 90 nTPM
Expression across tissuesHPA
Tissue
- skin: 90 nTPM
- heart muscle: 71 nTPM
- skeletal muscle: 62 nTPM
- thyroid gland: 55 nTPM
- vagina: 20 nTPM
- esophagus: 17 nTPM
Single-cell type
- basal keratinocytes: 370 nCPM
- ocular epithelial cells: 368 nCPM
- suprabasal keratinocytes: 350 nCPM
- respiratory ciliated cells: 236 nCPM
- ependymal cells: 173 nCPM
- cardiomyocytes: 140 nCPM
Immune cell
- memory CD8 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 15 nTPM
- hippocampal formation: 14 nTPM
- choroid plexus: 11 nTPM
- cerebellum: 10 nTPM
- medulla oblongata: 10 nTPM
- pons: 9.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.35
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.67
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PPP1R14C as an antibody target. Whether an autoantibody or antibody against PPP1R14C could matter depends on whether native PPP1R14C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PPP1R14C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PPP1R14C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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