Seroatlas · Human Serome Atlas

PPM1N

Probable protein phosphatase 1N

Also known as: FLJ40125, PPM1N_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N819
Gene: PPM1N
Ensembl: ENSG00000213889
Chromosome: 19
Canonical length: 430 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

430 residues, UniProt reviewed canonical sequence.

>Q8N819|PPM1N
     1  MAVLARQLQR LLWTACKKKE REKEGREEEE EEEAGRRAPE GPRSLLTAPR RAQRPHGGAE
    61  ASGGLRFGAS AAQGWRARME DAHCTWLSLP GLPPGWALFA VLDGHGGARA ARFGARHLPG
   121  HVLQELGPEP SEPEGVREAL RRAFLSADER LRSLWPRVET GGCTAVVLLV SPRFLYLAHC
   181  GDSRAVLSRA GAVAFSTEDH RPLRPRERER IHAAGGTIRR RRVEGSLAVS RALGDFTYKE
   241  APGRPPELQL VSAEPEVAAL ARQAEDEFML LASDGVWDTV SGAALAGLVA SRLRLGLAPE
   301  LLCAQLLDTC LCKGSLDNMT CILVCFPGAP RPSEEAIRRE LALDAALGCR IAELCASAQK
   361  PPSLNTVFRT LASEDIPDLP PGGGLDCKAT VIAEVYSQIC QVSEECGEKG QDGAGKSNPT
   421  HLGSALDMEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 167 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 167 nTPM
retina: 21 nTPM
spleen: 8 nTPM
testis: 4.3 nTPM
placenta: 3.9 nTPM
choroid plexus: 3.6 nTPM

Single-cell type

extravillous trophoblasts: 190 nCPM
breast myoepithelial cells: 72 nCPM
neutrophils: 53 nCPM
rod photoreceptor cells: 51 nCPM
hofbauer cells: 35 nCPM
kupffer cells: 31 nCPM

Immune cell

non-classical monocyte: 137 nTPM
intermediate monocyte: 22 nTPM
myeloid DC: 12 nTPM
neutrophil: 6.5 nTPM
naive CD8 T-cell: 6.4 nTPM
basophil: 6.3 nTPM

Brain region

white matter: 5.2 nTPM
cerebral cortex: 5 nTPM
amygdala: 4.2 nTPM
hippocampal formation: 3.9 nTPM
choroid plexus: 3.8 nTPM
hypothalamus: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 1.2
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1N as an antibody target. Whether an autoantibody or antibody against PPM1N could matter depends on whether native PPM1N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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