Seroatlas · Human Serome Atlas

PPM1M

Protein phosphatase 1M

Also known as: FLJ32332, PP2Ceta, PPM1M_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MI6
Gene: PPM1M
Ensembl: ENSG00000164088
Chromosome: 3
Canonical length: 459 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and manganese ion binding activity. Predicted to be involved in protein dephosphorylation and signal transduction. Predicted to be located in nucleus. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q96MI6|PPM1M
     1  MSAGWFRRRF LPGEPLPAPR PPGPHASPVP YRRPRFLRGS SSSPGAADAS RRPDSRPVRS
    61  PARGRTLPWN AGYAEIINAE KSEFNEDQAA CGKLCIRRCE FGAEEEWLTL CPEEFLTGHY
   121  WALFDGHGGP AAAILAANTL HSCLRRQLEA VVEGLVATQP PMHLNGRCIC PSDPQFVEEK
   181  GIRAEDLVIG ALESAFQECD EVIGRELEAS GQMGGCTALV AVSLQGKLYM ANAGDSRAIL
   241  VRRDEIRPLS FEFTPETERQ RIQQLAFVYP ELLAGEFTRL EFPRRLKGDD LGQKVLFRDH
   301  HMSGWSYKRV EKSDLKYPLI HGQGRQARLL GTLAVSRGLG DHQLRVLDTN IQLKPFLLSV
   361  PQVTVLDVDQ LELQEDDVVV MATDGLWDVL SNEQVAWLVR SFLPGNQEDP HRFSKLAQML
   421  IHSTQGKEDS LTEEGQVSYD DVSVFVIPLH SQGQESSDH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1M can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

spleen: 29 nTPM
lymph node: 28 nTPM
tonsil: 26 nTPM
thymus: 26 nTPM
blood vessel: 25 nTPM
ovary: 25 nTPM

Single-cell type

neutrophils: 57 nCPM
hofbauer cells: 47 nCPM
neutrophil progenitors: 42 nCPM
kupffer cells: 35 nCPM
late spermatids: 30 nCPM
monocytes: 30 nCPM

Immune cell

non-classical monocyte: 30 nTPM
neutrophil: 29 nTPM
classical monocyte: 24 nTPM
gdT-cell: 21 nTPM
T-reg: 21 nTPM
intermediate monocyte: 19 nTPM

Brain region

hypothalamus: 20 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 15 nTPM
white matter: 14 nTPM
medulla oblongata: 14 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein dephosphorylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1M as an antibody target. Whether an autoantibody or antibody against PPM1M could matter depends on whether native PPM1M is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1M is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1M as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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