Seroatlas · Human Serome Atlas

PPM1J

Protein phosphatase 1J

Also known as: DKFZp434P1514, FLJ35951, MGC19531, PP2Czeta, PPM1J_HUMAN, PPP2CZ

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JR12
Gene: PPM1J
Ensembl: ENSG00000155367
Chromosome: 1
Canonical length: 505 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q5JR12|PPM1J
     1  MLNRVRSAVA HLVSSGGAPP PRPKSPDLPN AASAPPAAAP EAPRSPPAKA GSGSATPAKA
    61  VEARASFSRP TFLQLSPGGL RRADDHAGRA VQSPPDTGRR LPWSTGYAEV INAGKSRHNE
   121  DQACCEVVYV EGRRSVTGVP REPSRGQGLC FYYWGLFDGH AGGGAAEMAS RLLHRHIREQ
   181  LKDLVEILQD PSPPPLCLPT TPGTPDSSDP SHLLGPQSCW SSQKEVSHES LVVGAVENAF
   241  QLMDEQMARE RRGHQVEGGC CALVVIYLLG KVYVANAGDS RAIIVRNGEI IPMSREFTPE
   301  TERQRLQLLG FLKPELLGSE FTHLEFPRRV LPKELGQRML YRDQNMTGWA YKKIELEDLR
   361  FPLVCGEGKK ARVMATIGVT RGLGDHSLKV CSSTLPIKPF LSCFPEVRVY DLTQYEHCPD
   421  DVLVLGTDGL WDVTTDCEVA ATVDRVLSAY EPNDHSRYTA LAQALVLGAR GTPRDRGWRL
   481  PNNKLGSGDD ISVFVIPLGG PGSYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPM1J can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 71 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 71 nTPM
testis: 66 nTPM
tongue: 26 nTPM
epididymis: 20 nTPM
skin: 19 nTPM
cerebellum: 17 nTPM

Single-cell type

late spermatids: 259 nCPM
early spermatids: 87 nCPM
late primary spermatocytes: 25 nCPM
pdcs: 21 nCPM
ependymal cells: 21 nCPM
undifferentiated spermatogonia: 10 nCPM

Immune cell

plasmacytoid DC: 75 nTPM
myeloid DC: 7.8 nTPM
non-classical monocyte: 4.8 nTPM
intermediate monocyte: 1.6 nTPM
total PBMC: 0.9 nTPM
naive B-cell: 0.8 nTPM

Brain region

thalamus: 17 nTPM
midbrain: 14 nTPM
cerebral cortex: 11 nTPM
amygdala: 10 nTPM
cerebellum: 9.4 nTPM
hypothalamus: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPM1J in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UBE2I

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPM1J as an antibody target. Whether an autoantibody or antibody against PPM1J could matter depends on whether native PPM1J is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPM1J is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPM1J as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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